Heritability of young- and old-onset ischaemic stroke

Bluher, A.; Devan, W. J.; Gieger, C.; Meschia, J. F.; Rosand, J.; Rolfs, A.; Kittner, S. J.; Mitchell, B. D.; O'Connell, J. R.; Cheng, Y.-C.; Holliday, E. G.; Nalls, M.; Parolo, S.; Bione, S.; Giese, A.-K.; Boncoraglio, G. B.; Maguire, J. M.; Müller-Nurasyid, M.

Title: Heritability of young- and old-onset ischaemic stroke
Creator: Bluher, A.; Devan, W. J.; Gieger, C.; Meschia, J. F.; Rosand, J.; Rolfs, A.; Kittner, S. J.; Mitchell, B. D.; O'Connell, J. R.; Cheng, Y.-C.; Holliday, E. G.; Nalls, M.; Parolo, S.; Bione, S.; Giese, A.-K.; Boncoraglio, G. B.; Maguire, J. M.; Müller-Nurasyid, M.
Relation: NHMRC.569257
Relation: European Journal of Neurology Vol. 22, Issue 11, p. 1488-1491
Publisher Link: http://dx.doi.org/10.1111/ene.12827
Publisher: Wiley-Blackwell
Resource Type: journal article
Date: 2015
Description: Background and purpose: Although the genetic contribution to stroke risk is well known, it remains unclear if young-onset stroke has a stronger genetic contribution than old-onset stroke. This study aims to compare the heritability of ischaemic stroke risk between young and old, using common genetic variants from whole-genome array data in population-based samples. Methods: This analysis included 4050 ischaemic stroke cases and 5765 controls from six study populations of European ancestry; 47% of cases were young-onset stroke (age < 55 years). To quantify the heritability for stroke risk in these unrelated individuals, the pairwise genetic relatedness was estimated between individuals based on their whole-genome array data using a mixed linear model. Heritability was estimated separately for young-onset stroke and old-onset stroke (age = 55 years). Results: Heritabilities for young-onset stroke and old-onset stroke were estimated at 42% (±8%, P < 0.001) and 34% (±10%, P < 0.001), respectively. Conclusions: Our data suggest that the genetic contribution to the risk of stroke may be higher in young-onset ischaemic stroke, although the difference was not statistically significant.
Subject: heritability; ischemic stroke; stroke
Identifier: http://hdl.handle.net/1959.13/1314907
Identifier: uon:22849
Identifier: ISSN:1351-5101
Language: eng
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